Strand IRIS generates clinical reports from VCF files obtained from somatic NGS testing using small panels with tens of genes as well as large panels with ≈500 genes. IRIS uses a thorough rule set and curation of the literature for automated effect prediction for variants in 520 genes, automated therapy annotation with AMP tiers for ≈112 FDA-approved targeted drugs and 748 targeted drugs overall over 181 drug classes, and automated identification of clinical trials from ≈68,000 clinical trials. IRIS has been tried and tested in over 5,000 reports, and covers the numerous subtleties that come with the field.

Our Variant Curation and Reporting services are powered by experience gained over tens of thousands of reports and a proven track record of variant curation under ACMG (germline) and AMP (somatic) guidelines. We help major Dx companies create curated variant databases or provide reporting-ready variant content.

We have reliable expertise in establishing limits of detection, sensitivity, specificity, and reproducibility for various variant types in somatic, germline, and liquid biopsy settings. Our services include both generation of data using appropriately sourced control samples (from commercial sources as well as from our own internal library of samples) as well as analysis of data generated by our customers to deliver analytical and clinical validation reports for CLIA, CAP and NY State certification.

Our software services teams help our customers streamline and automate their lab processes, including for ex.:

• deployment and scale-up of secondary analysis (fastq to variant calls)
• streamlining of tertiary analysis (variant calls to reports)
• ordering and report delivery (physician portals)
• supporting research infrastructure (e.g., EDC systems for clinical research, aggregate data pools for mining)