Strand Life Sciences

Explore our tests

Hereditary Cancer Types & Genes

The various risk genes for 11 common cancer types covered by our test are in the table below.

ACMG recommended

APC, BMPR1A, BRCA1, BRCA2, MEN1, MSH1, MSH2, MSH6, MUTYH, NF2, PMS2, PTEN, RB1, RET, SDHAF2, SDHB, SDHC, SDHD, SMADA, STK11, TP53, TSC1, TSC2, VHL, WT1

Breast and ovarian cancer

ATM, BRCA1, BRCA2, BRIP1, CDM1, CHek2, NBN, PALB2, PTEN, RAD51C, RAD51D, TP53

Colorectal Cancer

ATM, BRCA1, BRCA2, BRIP1, CDM1, CHek2, NBN, PALB2, PTEN, RAD51C, RAD51D, TP53

Endocrine cancer

ATM, BRCA1, BRCA2, BRIP1, CDM1, CHek2, NBN, PALB2, PTEN, RAD51C, RAD51D, TP53

Gynaecological cancer

ATM, BRCA1, BRCA2, BRIP1, CDM1, CHek2, NBN, PALB2, PTEN, RAD51C, RAD51D, TP53

Sequencing Cancer Risk Genes

Our tests sequence all coding regions of the above genes to identify all potential genomic variants in these genes. We have the experience of having run tens of thousands of these tests. We were the first to publish experiences from large scale testing in India along with leading oncologists.

Coverage

The number of times each genomic character is read is an important parameter of test quality. Our tests read each relevant character 400 times on average, to ensure accuracy.

Variant Types

Because of our exquisite coverage and our long history of bioinformatics, we can call genomic variants that span several hundreds or even thousands of genomic characters very effectively.

Variant Interpretation

Our bioinformatics platforms built completely in house have been at work for over a decade to allow accurate identification of the relevant variants. Many tens or hundreds of variants that are found are carefully examined in the light of scientific evidence for their role in cancer risk, using the criteria laid out by guidelines from the American College of Medical Genetics. Those that reach the evidence level of Pathogenic or Likely Pathogenic are reported along with those that carry considerable uncertainty, i.e. Variants of Unknown Significance.

Test Portfolio

Test Name

No.of genes

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Germline Panel – Prostrate Cancer

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12

Germline Panel – Colorectal Cancer

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14

Germline Panel – Endocrine Cancer

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11

Germline Panel – Gynaecological Cancer

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12

Germline Panel – Nervous System Cancer

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16

Germline Panel – Pancreatic Cancer

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14

Germline Panel – Prostate Cancer

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12

Germline Panel – Renal Cancer

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7

Germline Panel – Skin Cancer

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10

Germline BRCA with reflex MLPA

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2