Explore our tests
Hereditary Cancer Types & Genes
The various risk genes for 11 common cancer types covered by our test are in the table below.
ACMG recommended
APC, BMPR1A, BRCA1, BRCA2, MEN1, MSH1, MSH2, MSH6, MUTYH, NF2, PMS2, PTEN, RB1, RET, SDHAF2, SDHB, SDHC, SDHD, SMADA, STK11, TP53, TSC1, TSC2, VHL, WT1
Breast and ovarian cancer
ATM, BRCA1, BRCA2, BRIP1, CDM1, CHek2, NBN, PALB2, PTEN, RAD51C, RAD51D, TP53
Colorectal Cancer
ATM, BRCA1, BRCA2, BRIP1, CDM1, CHek2, NBN, PALB2, PTEN, RAD51C, RAD51D, TP53
Endocrine cancer
ATM, BRCA1, BRCA2, BRIP1, CDM1, CHek2, NBN, PALB2, PTEN, RAD51C, RAD51D, TP53
Gynaecological cancer
ATM, BRCA1, BRCA2, BRIP1, CDM1, CHek2, NBN, PALB2, PTEN, RAD51C, RAD51D, TP53
Sequencing Cancer Risk Genes
Our tests sequence all coding regions of the above genes to identify all potential genomic variants in these genes. We have the experience of having run tens of thousands of these tests. We were the first to publish experiences from large scale testing in India along with leading oncologists.
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Coverage
The number of times each genomic character is read is an important parameter of test quality. Our tests read each relevant character 400 times on average, to ensure accuracy.
Variant Types
Because of our exquisite coverage and our long history of bioinformatics, we can call genomic variants that span several hundreds or even thousands of genomic characters very effectively.
Variant Interpretation
Our bioinformatics platforms built completely in house have been at work for over a decade to allow accurate identification of the relevant variants. Many tens or hundreds of variants that are found are carefully examined in the light of scientific evidence for their role in cancer risk, using the criteria laid out by guidelines from the American College of Medical Genetics. Those that reach the evidence level of Pathogenic or Likely Pathogenic are reported along with those that carry considerable uncertainty, i.e. Variants of Unknown Significance.
Test Portfolio
Test Name
No.of genes
Select
Germline Panel – Prostrate Cancer
12
Germline Panel – Colorectal Cancer
14
Germline Panel – Endocrine Cancer
11
Germline Panel – Gynaecological Cancer
12
Germline Panel – Nervous System Cancer
16
Germline Panel – Pancreatic Cancer
14
Germline Panel – Prostate Cancer
12
Germline Panel – Renal Cancer
7
Germline Panel – Skin Cancer
10
Germline BRCA with reflex MLPA
2