In AneuXpress, QF-PCR is used to determine the relative amounts of DNA from different chromosomes, indicating whether there is an abnormal number of each chromosome (aneuploidy). As the DNA is amplified during PCR, the fluorescent signal increases, allowing for the quantification of the target DNA, which can be used to identify the numbers of chromosomes in the sample.
- Rapid prenatal diagnosis of common fetal aneuploidies.
- Cases requiring quick results, such as in situations with late-stage pregnancies or urgent medical decisions.
- Confirmation of positive NIPS results.
- Cases where invasive prenatal testing (amniocentesis or chorionic villus sampling) has been performed, and rapid results are needed.
