The Somatic Advantage 74 Reflex is a dual-approach molecular profiling strategy. It begins with the analysis of mutations in 74 genes using DNA sequencing and fusions in 14 genes using RNA sequencing from a tissue biopsy. If tissue analysis is inconclusive, inadequate, or unavailable, the test automatically reflexes to a liquid biopsy, ensuring comprehensive results without requiring a separate request.
Patients where tissue testing may not yield adequate results, or where backup analysis is needed.
All Solid Tumors, Comprehensive Profiling
Methodology: | NGS |
Depth of Coverage: | >1000x (Tissue) >2000x (Liquid Biopsy) |
Limit of Detection: | Tissue: 5% VAF (SNV and Indels), ≥4.5 Copies of amplified genes (CNVs), ≥4 Copies/ng expression of fused gene Liquid Biopsy: 0.5% VAF (SNV and Indels), 0.3% VAF (Fusions) |
Sample Type: | FFPE & Blood |
Container: | FFPE: Plastic container Blood: Streck Tube |
Shipping Conditions: | Ambient (15-22 ⁰C) |
Max Transit Time: | FFPE: 5-6 Days Blood: 48-72 hrs |
22 Days