Lynch Syndrome Panel

Test Code
SLS161004
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What is the Lynch Syndrome Panel?

Lynch syndrome is the most common cause of hereditary colorectal and endometrial cancers. It results from mutations in DNA mismatch repair (MMR) genes, leading to increased cancer susceptibility at a young age. The Lynch Syndrome Panel identifies mutations in key MMR genes, helping guide surveillance and preventive strategies.

Genes Covered/No of Genes: EPCAM, MLH1, MSH2, MSH6, PMS2

Indications for Testing

  • Patients diagnosed with colorectal or endometrial cancer at a young age.
  • Individuals with multiple Lynch syndrome-related cancers in the family.
  • Patients meeting the revised Bethesda or Amsterdam criteria for Lynch syndrome.

Inheritance Pattern

Autosomal dominant mutations in mismatch repair (MMR) genes lead to microsatellite instability and increased cancer risk.

Why is This Test Important?

Early identification enables increased surveillance and preventive interventions.
Colorectal Cancer, Endometrial Cancer, Stomach Cancer, Small Intestine Cancer, Ovarian Cancer, Kidney Cancer, Ureter Cancer, Pancreatic Cancer, Liver Cancer, Brain Cancer, Bladder Cancer, Prostate Cancer

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