HBOC Basic Panel

Test Code
SLS161002
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The HBOC Basic Panel screens for mutations in the most common genes associated with Hereditary Breast and Ovarian Cancer (HBOC) syndrome, including BRCA1, BRCA2, and other high-risk genes.

Genes Covered/No of Genes: BRCA1, BRCA2, PALB2, TP53

Indications for Testing

  • Patients with early-onset breast, ovarian, bilateral breast cancer, Prostate cancer, or peritoneal cancers.
  • Those with a family history of HBOC-related cancers, sarcomas, prostate cancers etc.
  • Individuals of Ashkenazi Jewish descent, who have a higher prevalence of BRCA mutations.

Inheritance Pattern

Autosomal dominant—P/LP mutations in these genes confer a high/increased risk of hereditary cancers.

Why is This Test Important?

Testing enables risk assessment and personalized treatment strategies, including the use of targeted therapies like PARP inhibitors, surgical managements, and personalised surveillance plans.

BRCA1, BRCA2, PALB2, TP53

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