Germline Panel – Pancreatic Cancer

Test Code
SLS161011
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What is the Germline Panel - Pancreatic Cancer?

The Germline Panel – Pancreatic Cancer evaluates genetic mutations that increase the risk of hereditary pancreatic cancer, including BRCA1, BRCA2, and PALB2.

While most pancreatic cancers occur sporadically, around 5–10% have a hereditary component linked to genetic syndromes such as hereditary breast and ovarian cancer (HBOC), Lynch syndrome, Peutz-Jeghers syndrome, and familial atypical multiple mole melanoma (FAMMM) syndrome. Genetic testing helps identify high-risk individuals who may benefit from early screening and personalized treatment strategies.

Genes Covered/No of Genes: APC, ATM, BRCA1, BRCA2, CDKN2A, EPCAM, MLH1, MSH2, MSH6, PALB2, SMAD4, STK11,TP53, VHL

Indications for Testing

  • Individuals with a family history of pancreatic cancer.
  • Patients diagnosed with pancreatic cancer under 50 years of age or with multiple primaries.
  • Those with known BRCA1/BRCA2-associated cancers in the family.

Inheritance Pattern

Autosomal dominant, with genes like BRCA2, PALB2, and STK11 (Peutz-Jeghers syndrome) showing moderate-to-high risk.

Why is This Test Important?

Testing can guide early screening (e.g., MRI/ERCP) and consideration for targeted therapies (e.g., PARP inhibitors).
Pancreatic Cancer

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