Germline Panel – Nervous System Cancer

Test Code
SLS161009
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What is the Germline Panel - Nervous System Cancer?

The Germline Panel – Nervous System Cancer detects hereditary mutations linked to nervous system cancers, including gliomas and neurofibromatosis-related tumors.

Hereditary nervous system cancers include conditions like neurofibromatosis (NF1/NF2), Li-Fraumeni syndrome, and von Hippel-Lindau disease, which increase the risk of brain tumors, spinal cord tumors, and nerve sheath tumors. Identifying inherited mutations allows for early surveillance, risk-reduction strategies, and specialized treatment approaches.

Genes Covered/No of Genes: ALK, APC, EPCAM, MEN1, MLH1, MSH2, MSH6, NF2, PHOX2B,PMS2, PTEN, SUFU,TP53,TSC1,TSC2, VHL

Indications for Testing

  • Patients with early-onset or multiple brain tumors.
  • Individuals with neurofibromatosis or a family history of nervous system tumors.
  • Children with adrenal or neural crest tumors (e.g., neuroblastoma).

Inheritance Pattern

Autosomal dominant, with conditions like NF1/NF2, Li-Fraumeni syndrome (TP53), and von Hippel-Lindau (VHL) showing high penetrance.

Why is This Test Important?

Early genetic diagnosis can enable close monitoring, surgical decisions, and targeted therapy in high-risk individuals.
Nervous System Cancer

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