Germline 3 Gene Panel

Test Code
SLS161001
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What is the Germline 3 Gene Panel?

The Germline 3 Gene Panel evaluates BRCA1, BRCA2, and TP53—three critical genes linked to hereditary cancer syndromes. While BRCA1/BRCA2 mutations are associated with HBOC, TP53 mutations are linked to Li-Fraumeni syndrome, which increases the risk of multiple early-onset cancers, including sarcomas, breast cancer, brain tumors, and leukemia.

Genes Covered/No of Genes: BRCA1, BRCA2, TP53

Indications for Testing

  • Patients with early-onset breast cancer or multiple primary cancers.
  • Individuals with a family history of BRCA1/BRCA2 or TP53-related cancers.
  • Those with a history of childhood sarcomas or brain tumors (suggestive of LFS).
  • To guide treatment decisions, including chemotherapy sensitivity (e.g., TP53 mutations may impact response) and  planning radiation therapy.

Inheritance Pattern

P/LP mutations in these genes follows autosomal dominant pattern of inheritance which lead to a significantly increased lifetime risk of cancer. First-degree relatives have a 50% chance of inheriting the mutation.

Why is This Test Important?

Identifying mutations in BRCA1, BRCA2, or TP53 genes enables early intervention and tailored cancer prevention strategies.

Breast Cancer, Ovarian Cancer, Fallopian Tube Cancer, Prostate Cancer,Testicular Cancer, Pancreatic Cancer, Uterine Cancer, Cervical Cancer, Skin Cancer, Brain Cancer, Hematologic Cancer, Liver Cancer, Soft Tissue Sarcoma, Adrenal Cancer

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