Endometrial Cancer Test

Test Code
SLS162900

What is the Endometrial Cancer Test?

This test detects mutations in key genes associated with endometrial cancer subtypes. It aids in classifying the tumor into distinct molecular subgroups, which is essential for tailoring treatment strategies and assessing prognosis.

Genes Covered: dMMR mutations, POLE, TP53

Who Is This Test For?

Patients diagnosed with endometrial cancer who need a molecular profile to determine treatment or assess hereditary risk.

Key Features

  • Analyzes genes involved in DNA mismatch repair (dMMR): MLH1, MSH2, MSH6, PMS2
  • Includes evaluation of POLE (ultramutated subtype) and TP53 (copy number-high subtype)
  • Facilitates molecular classification (e.g., dMMR, POLE-mutated, p53-abnormal, NSMP)

Clinical Applications

  • Supports immunotherapy selection (especially in dMMR-positive tumors)
  • Assists in prognostic stratification and personalized treatment planning

Endometrial Cancer

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